Pain Models

At APS, we rigorously characterize and validate our models so that you can make informed decisions about the study design and collect the most reliable data possible. Through our validation process, we understand the time course and magnitude of each pain-related behavior and we use clinically-relevant analgesics to characterize the sensitivity of each endpoint in each model. Our highly-trained staff are capable of dosing via standard and specialized routes (including spinal delivery).

Non-Genetic (Created) Disease Models

SNL - Spinal Nerve Ligation
CCI - Chronic Constriction Injury
LPA - Lysophosphatidic Acid
Fibromyalgia

Bone and Joint Pain

MIA-OA - Monosodium Iodoacetate - Induced Osteoarthritis
CFA-Arthritis - Complete Freund's Adjuvant Arthritis
MRMT - Minnesota Rate of Manipulation Tests- induced bone cancer pain

Inflammation and Inflammatory Pain

CFA - Complete Freund's Adjuvant
UVB - Ultraviolet B Irradiation-induced inflammation
Carrageenan
Formalin

Post Surgical Pain

Plantar

Acute and Chemogenic Pain

Hot Plate
Tail Flick
Capsaicin
Acetic Acid Writhing

Adverse Event Profiling

Rotorod
GIT - Gastrointestinal Transit
FOB - Functional Observational Battery

Visceral Pain

Colorectal Distention
Urinary Bladder Sensitivity

To download a copy of the APS Pain Model Catalog, please fill out the information below.

Toxicology & Pharmacology

Toxicology & Pharmacology
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Pain Research

Pain Research
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Surgical Medical Device Research

Surgical Medical Device Research
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Scientific Team

Scientific Team
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Surfaces Biomaterial Foundations

American Association for Laboratory Animal Science