Interventional Medical Device Research

American Preclinical Services (APS) continues to be a preclinical center of excellence for interventional research to meet all of your model development, treatment, and/or implant requirements.

Our Interventionalists are highly trained and experience, having trained with some of the most prominent doctors and researchers in the world.

Imaging and Data Collection Modalities

APS offers cutting edge equipment and interventional techniques specifically designed for cardiovascular and peripheral vascular research. APS has four digital cardiac catheterization labs featuring the Siemens AXIOM Artis and Zee fixed C-arm platforms. By having four interchangeable cath labs, and offering the highest quality digital imaging possible, APS can accommodate your timelines no matter how large the study design or last minute the request. Furthermore, our in-house technical experts are among the most experienced interventionalists in preclinical research.

We feature dedicated Siemens Leonardo workstations in each cath lab for real-time quantitative coronary/vascular angiography (QCA/QVA) analysis and evaluation.

Quantitative angiography may be augmented by additional types of intravascular imaging, including optical coherence tomography (OCT), intravascular ultrasound (IVUS), and intracardiac ultrasound (ICE).

APS also operates its own dedicated picture archiving and communication system (PACS) server for storing and retrieving cases.

Fluoroscopy (Siemens AXIOM Artis and Zee™ Digital Cath Labs (n=4), Siemens Avantic™(two) and GE OEC mobile c-arms)
3D Rotational Fluoroscopy
Intravascular Ultrasound (IVUS) (Boston Scientific iLAB™)
Optical Coherence Tomography (OCT) (Abbott Ilumien Optis)
Intracardiac echo (ICE) and Ultrasound (St. Jude Medical Zonare, Philips iE33, Siemens Cypress II and Sequoia™)
EP Mapping (Ensite Velocity)
EP Recording (Boston Scientific LabSystem™ PRO)
Dual Source Computed Tomography (CT) (Siemens Somatom® Definition)
MicroCT (Optiv CT160)

Diagnostic Imaging Modalities through Partnerships

Through trusted partners, APS is able to offer additional diagnostic imaging and analysis. All work performed with our partners is contracted and supervised by APS's personnel. These partnerships give APS access to a network of experts to assist in study design and interpretation of results.

MRI (Siemens Avanto 1.5T, GE Signa HDx 3.0T)

APS is experienced in the following interventional models and device product testing:

Cardiovascular

Transcatheter Valve Replacement (TAVI, TAVR)
Aortic Annuloplasty Balloons
Septal Defect Closure (ASD, PFO, PMVSD)
Left Atrial Appendage Occlusion
Patent ductus Arteriosus Closure
Perivalvular Leak Occlusion
Coronary Drug Eluting Stents and Scaffolds (DES)
Coronary Bare Metal Stents (BMS)
Peripheral Drug Eluting Stents and Scaffolds (DES)
Peripheral Bare Metal Stents (BMS)
Guide Wires
Guide Catheters
Transseptal Catheters
Introducer Sheaths
Drug Coated Balloons (DCB / DEB)
POBA Balloons
Renal Denervation
Myocardial Infarction Models
Embolic Beads
Embolic Protection
Abdominal Aortic Aneurysm (AAA)
Endovascular Grafts
Atherectomy
Thrombectomy
Chronic Total Occlusion / Total Partial Occlusion Crossing Wires (CTO)
Vascular Closure
Cell and Gene Therapy
Vascular Stimulation
Telemetry

Electrophysiology

Cardiac Ablation
Cardiac Rhythm Management
Cardiac Leads
Pulmonary Vein Ablation
EP Recording and Mapping

Gastrointestinal

Obesity Devices
Biliary Catheter

Neuromodulation

Epidural leads
Carotid Sinus Stimulation

Pulmonary

Lung denervation
Lung Volume Reduction
Lung Biopsy
Drug Eluting Stents and Scaffolds (DES)
Bare Metal Stents and Scaffolds
Tracheal Stent

Urogenital

Kidney Cellular Regeneration
Prostate Ablation
Uterine Ablation

Your trusted resource for a full range of preclinical services.

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